Michal Nesázal graduated from the Academy of Fine Arts in Prague in 1991 in the painting studio of Jiří Sopek. He was a founding member of the group Pondelí (1989–1993), whose other members included Milena Dopitová, Pavel Humhal, Petr Lysáček, Petr Pisařík and Petr Zubek. In 1992 he received the Jindřich Chalupecký Award. Since 1992 he has regularly completed a number of study stays abroad in Australia, the USA and China.